September 2008

Substitution of Alimta/Carboplatin for Alimta/Cisplatin

In reviewing the scientific evidence for substituting Carboplatin for Cisplatin it appears that there is very little difference in response rate and survival.   Why do oncologists persist in using Cisplatin as first line? It is data driven.  Cisplatin/Alimta was a randomized placebo controlled trial that compared Alimta/Cisplatin to Cisplatin plus placebo.  In this trial 456 patients participated and a […]